منابع مشابه
Decoding Dopamine Signaling
Dopamine is a key neurotransmitter that is important for many physiological functions including motor control, mood, and the reward pathway. In this issue of Cell, the laboratories of Marc Caron and Li-Huei Tsai identify two very different molecules--beta-arrestin 2 and Par-4, respectively--that unexpectedly are involved in dopamine signaling via the D2 receptor. These two new signaling pathway...
متن کاملDecoding endocannabinoid signaling.
JZL184, is a covalent inactivator that exhibits a half-maximal inhibitory concentration (IC50) for MAGL of 8 nM (its IC50 for FAAH is 4 μM). JZL184 doesn’t inhibit any of 40 other serine hydrolases in the mouse brain membrane proteome. When administered to mice, JZL184 inhibits MAGL activity by 85% and induces a prolonged eightfold increase in the level of 2-AG in the brain while not increasing...
متن کاملThe neurobiology of dopamine signaling.
The brain contains 2 major groups of dopamine neurons. One is located in the arcuate nucleus of the hypothalamic median eminence and is involved in neuroendocrine regulation. The other, which is the subject of this article, is located in the ventral mesencephalon and projects to the forebrain. Although dopamine neurons are few (<1/100 000 brain neurons), they play an important role in regulatin...
متن کاملReward signaling by dopamine neurons.
Dopamine projections from the midbrain to the striatum and frontal cortex are involved in behavioral reactions controlled by rewards, as inferred from deficits in parkinsonism, schizophrenia, and drug addiction. Recent experiments have shown that dopamine neurons are not directly modulated in relation to movements. Rather, they appear to code the rewarding aspects of environmental stimuli. They...
متن کاملDopamine signaling: target in glioblastoma
Despite numerous promising discoveries in contemporary cancer research, and the emerging innovative cancer treatment strategies, the global burden of malignant diseases is expected to rise, in part due to the rapidly aging human populations. Consequently, there is an urgent need to design and validate new treatments in oncology, especially for cancer types with presently dismal prognosis due to...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.07.011